About us

We are located in the Division of Signaling and Functional Genomics at the German Cancer Research Center (DKFZ) in Heidelberg.


 

Fillip Port, PhD
Fillip set up CRISPRflydesign in 2013, while a postdoc in Simon Bullock’s lab at the Laboratory of Molecular Biology in Cambridge. In 2016 he joined the Division of Signaling and Functional Genomics at the DKFZ Heidelberg, where he continues to develop and apply Drosophila CRISPR tools for functional genomics. He maintains the website and twitter feed and you can contact him with any questions or comments about the project. Send an email.
Before joining the DKFZ, Fillip did a PhD with Koni Basler in Zurich studying Wnt secretion and a postdoc with Simon Bullock in Cambridge working on mRNA localisation and CRISPR method development. He is from a small village in central Germany.

 

Michael Boutros, PhD
Michael is head of the Division of Signaling and Functional Genomics at the German Cancer Research Center (DKFZ). His lab is studying signaling networks in development and cancer. A particular focus of the group is on high-throughput methods for systematic functional analysis of cellular processes to identify vulnerabilities of cancer cells. Learn more about our work here.
Michael did a PhD with Marek Mlodzik at EMBL and a postdoc with Norbert Perrimon at Harvard Medical School. He established his lab at the DKFZ in 2003 and since 2008 is head of the Functional Genomics Division and full professor at Heidelberg University.

 

Claudia Strein
Claudia trained as a technician at the DKFZ Heidelberg graduating in 1993. After working in two pharma companies she joined Matthias Hentze’s lab at EMBL. There she worked on developing the novel ‘interactome capture method’ to identify RNA-binding proteins.In 2013 she joined the Division of Signaling and Functional Genomics at the DKFZ, where she worked on a genome-wide RNAi screen in Drosophila melanogaster. In 2016 she joined the CRISPRflydesign team to develop systematic resources for CRISPR knock-out screening.

 

monaweb
Mona Stricker
Mona trained as a medical technical assistant at the Theresienhospital in Mannheim. Afterwards she worked on autoantibodies with Dr. Seelig in Karlsruhe and at the German Resource Center for Genome Research in Heidelberg. She joined the DKFZ in 2001 and the Division of Signaling and Functional Genomics in 2004. In 2016 she joined our team to help build our transgenic gRNA library. After the lab she loves indoor cycling to take her mind off work.

 

Nora Langner
Nora grew up in a (very) small town close to the Baltic sea. After finishing her A-levels in 2019 she joined the DKFZ for a gap year to gain insights into the inner workings of a research lab. She is generating new lines for the sgRNA library and tests various aspects of our genome engineering system. After her stay in our group she plans to study a STEM subject. Nora is playing the piano and together with her sister makes the best chocolat pralines in Heidelberg.

 

Laura Lange
Laura is from Waldprechtsweier, a small town south of Karlsruhe. But after spending too much time on German trains she is now living in Heidelberg. Laura is also doing a gap year between her A-levels and university in order to gain practical experience in the lab. Afterwards she plans to study molecular biology. Laura is helping us generate the CRISPR library and uses CRISPR mutagenesis to systematically test the role of genes during Drosophila development.

 

Alumni:

 

Ainoa Tejedera (05/19 – 08/19)
Amy Hess (09/18 – 08/19)
Celine Beyersdörffer (09/18 – 06/19)
Maja Starostecka (11/17 – 10/18)
Roberta Malamud (09/17 – 08/18)
Lukas Schmitt (09/17 – 06/18)
Kristin Rädecke (01/18 – 03/18)
Lukas Voos (09/16 – 08/17)
Katharina Kern (09/16 – 07/17)
Jana Frei (09/2016 – 04/2017)
Mariane Dahmer (02/2017 – 03/2017)

 

Join us! If you are interested to join our team and develop and apply new CRISPR technologies than please contact Fillip or Michael informally to discuss possibilities.

 
 

The CFD team 2019/2020: Nora, Laura, Mona, Claudia, Fillip

 
 

The CFD team 2018/2019: Claudia, Celine, Fillip, Amy, Mona

 
 

The CFD team 2016/2017: Mona, Jana, Katharina, Claudia, Fillip, Lukas
teamcfd_web2

 
 

CRISPRflydesign at the Laboratory of Molecular Biology in Cambridge

 

Nadine_webCFD Nadine Muschalik, PhD

Nadine is a joint research support officer in the Bullock and Munro labs. Her work focuses on developing new tools for genome engineering and applying these to study intracellular vesicle trafficking.

Before coming to Cambridge, Nadine did a Postdoc with Jordan Raff in Oxford on centriole assembly and a PhD with Eli Knust in Dresden on cell polarity. She is from Dusseldorf in Western Germany.

 

 

 

 

 

Simon Bullock, PhD

Simon’s lab studies cargo transport by molecular motors in vivo and in vitro using single molecule assays. Find out more about what we do on our group website.

Before setting up his group at the LMB Simon did a Postdoc with David Ish-Horowitz in London studying mRNA localization in Drosophila. Previous to that he did a PhD with Rosa Beddington studying mouse embryonic development. He is from Yorkshire in North England.

 

 

 

 

 


Contributors:

Hui-Min Chen & Tzumin Lee

Janelia Research Campus, HHMI, Ashburn, USA

Hui-Min and Tzumin generated our fly lines CFD5 and CFD6 and posted some of the earliest results of fully transgenic CRISPR/Cas on the site. They have since also published their own CRISPR system called Golic+ (paper).

 

Kate Koles & Avi Rodal

Brandeis University, Waltham, USA

Kate and Avi have generated and tested line CFD8.

 

David Stern

Janelia Research Campus, HHMI, Ashburn, USA

David has generated nos-cas9 transgenic D. yakuba, D. simulans and D. mauritiana lines, which he is freely sharing with the community.