About us

We are located in the Division of Signaling and Functional Genomics at the German Cancer Research Center (DKFZ) in Heidelberg.


 

Fillip Port, PhD
Fillip set up CRISPRflydesign in 2013, while a postdoc in Simon Bullock’s lab at the Laboratory of Molecular Biology in Cambridge. In 2016 he joined the Division of Signaling and Functional Genomics at the DKFZ Heidelberg, where he continues to develop and apply Drosophila CRISPR tools for functional genomics. He maintains the website and twitter feed and you can contact him with any questions or comments about the project. Send an email.
Before joining the DKFZ, he did a PhD with Koni Basler in Zurich studying Wnt secretion and a postdoc with Simon Bullock in Cambridge working on mRNA localisation and CRISPR method development. He is from a small village in central Germany.

 

Michael Boutros, PhD
Michael is head of the Division of Signaling and Functional Genomics at the German Cancer Research Center (DKFZ). His lab is studying signaling networks in development and cancer. A particular focus of the group is on high-throughput methods for systematic functional analysis of cellular processes to identify vulnerabilities of cancer cells. Learn more about our work here.
Michael did a PhD with Marek Mlodzik at EMBL and a postdoc with Norbert Perrimon at Harvard Medical School. He established his lab at the DKFZ in 2003 and since 2008 is head of the Functional Genomics Division and full professor at Heidelberg University.

 

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Jana Frei
Jana is a master student in biochemistry at the University of Tübingen. She joined the lab in 2016 for an internship and is currently doing her master thesis. Jana performs a tissue-specific CRISPR screen using the UAS-t:gRNA lines we are generating.Before joining the lab Jana did internships with Dr. Bronwen Connor at the University of Auckland, New Zealand, and at the Max-Planck-Institute for Developmental Biology, Tübingen (Laboratory of Prof. Dr. Christiane Nüsslein-Volhard). During her lab placements she already gained experience with CRISPR/Cas genome engineering in zebrafish and in human HDF cells. Jana is from Stuttgart in the southwest of Germany.

 

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Katharina Kern
Katharina is doing an apprenticeship at the DKFZ Heidelberg since 2015 and joined the Division of Signaling and Functional Genomics in 2016. In her first year she worked in the Developmental Immunology Department with Bruno Kyewski and K. Rattay and studied mosaic expression patterns of mTECs for central tolerance in mice.Before starting the apprenticeship she did her A-levels at the Biotechnology School in Bruchsal. Katharina is a competitive football player and likes making music.

 

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Claudia Strein
Claudia trained as a technician at the DKFZ Heidelberg graduating in 1993. After working in two pharma companies she joined Matthias Hentze’s lab at EMBL. There she worked on developing the novel ‘interactome capture method’ to identify RNA-binding proteins.In 2013 she joined the Division of Signaling and Functional Genomics at the DKFZ, where she worked on a genome-wide RNAi screen in Drosophila melanogaster. In 2016 she joined the CRISPRflydesign team to develop systematic resources for CRISPR knock-out screening.

 

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Mona Stricker
Mona trained as a medical technical assistant at the Theresienhospital in Mannheim. Afterwards she worked on autoantibodies with Dr. Seelig in Karlsruhe and at the German Resource Center for Genome Research in Heidelberg. She joined the DKFZ in 2001 and the Division of Signaling and Functional Genomics in 2004. In 2016 she joined our team to help build our transgenic gRNA library. After the lab she loves indoor cycling to take her mind off work.

 

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Lukas Voos
Lukas is doing a voluntary year at the DKFZ Heidelberg since September 2016. After doing his A-levels he wanted to gain first hand experience in science before deciding what courses to take at university. He was born in Freiburg and lived in Rheinbach near Bonn for the last 8 years.

 

Mariane Dahmer
Mariane is a master student in molecular biosciences and does a lab rotation with us. She is from Brazil and studied biology at the University of Santa Catarina, before entering the master programs of the LMU Munich and since 2015 the University of Heidelberg. She is exploring various applications of our gRNA library in cultured cells.

Join us! We are currently looking for a PhD student. Please apply to the DKFZ PhD programm by 31. May 2017 and contact Fillip or Michael informally. We also have an opening for a master student. Please email us if you are interested.

 

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CRISPRflydesign at the Laboratory of Molecular Biology in Cambridge

 

Nadine_webCFD Nadine Muschalik, PhD

Nadine is a joint research support officer in the Bullock and Munro labs. Her work focuses on developing new tools for genome engineering and applying these to study intracellular vesicle trafficking.

Before coming to Cambridge, Nadine did a Postdoc with Jordan Raff in Oxford on centriole assembly and a PhD with Eli Knust in Dresden on cell polarity. She is from Dusseldorf in Western Germany.

 

 

 

 

 

Simon Bullock, PhD

Simon’s lab studies cargo transport by molecular motors in vivo and in vitro using single molecule assays. Find out more about what we do on our group website.

Before setting up his group at the LMB Simon did a Postdoc with David Ish-Horowitz in London studying mRNA localization in Drosophila. Previous to that he did a PhD with Rosa Beddington studying mouse embryonic development. He is from Yorkshire in North England.

 

 

 

 

 


Contributors:

Hui-Min Chen & Tzumin Lee

Janelia Research Campus, HHMI, Ashburn, USA

Hui-Min and Tzumin generated our fly lines CFD5 and CFD6 and posted some of the earliest results of fully transgenic CRISPR/Cas on the site. They have since also published their own CRISPR system called Golic+ (paper).

 

Kate Koles & Avi Rodal

Brandeis University, Waltham, USA

Kate and Avi have generated and tested line CFD8.

 

David Stern

Janelia Research Campus, HHMI, Ashburn, USA

David has generated nos-cas9 transgenic D. yakuba, D. simulans and D. mauritiana lines, which he is freely sharing with the community.